Assay Detail
Functional
CHEMBL1817185
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Cytotoxicity against human paclitaxel resistant K562 cells after 3 days by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and significant cytostatic activity of 7-hetaryl-7-deazaadenosines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.32 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 8.22 |
| CHEMBL1814773 | — | — | 1 | 8.05 |
| CHEMBL1814768 | — | — | 1 | 7.33 |
| CHEMBL1814774 | — | — | 1 | 7.04 |
| CHEMBL1814770 | — | — | 1 | 7.03 |
| CHEMBL1814769 | — | — | 1 | 6.83 |
| CHEMBL1619 | CLADRIBINE | 4.0 | 1 | 6.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL888 | GEMCITABINE | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1814773 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1814768 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL1814774 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL1814770 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL1814769 | — | IC50 | = | 147.0 | nM | 6.83 |
| CHEMBL1619 | CLADRIBINE | IC50 | = | 170.0 | nM | 6.77 |