Assay Detail
Functional
CHEMBL1817188
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Cytotoxicity against mouse L1210 cells after 3 days by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and significant cytostatic activity of 7-hetaryl-7-deazaadenosines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.89 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 8.15 |
| CHEMBL1814773 | — | — | 1 | 7.08 |
| CHEMBL1814768 | — | — | 1 | 6.94 |
| CHEMBL1814770 | — | — | 1 | 6.70 |
| CHEMBL1814774 | — | — | 1 | 6.59 |
| CHEMBL1619 | CLADRIBINE | 4.0 | 1 | 6.41 |
| CHEMBL1814769 | — | — | 1 | 6.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL888 | GEMCITABINE | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1814773 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL1814768 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL1814770 | — | IC50 | = | 199.0 | nM | 6.70 |
| CHEMBL1814774 | — | IC50 | = | 258.0 | nM | 6.59 |
| CHEMBL1619 | CLADRIBINE | IC50 | = | 393.0 | nM | 6.41 |
| CHEMBL1814769 | — | IC50 | = | 445.0 | nM | 6.35 |