Assay Detail
Binding
CHEMBL1817446
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Inhibition of mouse TDO expressed in mouse P815B cells assessed as inhibition of tryptophan catabolism by measuring kynurenine production after 8 hrs by HPLC analysis
76
Total Activities
76
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | P815B |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 76 | 5.03 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1812539 | — | — | 1 | 6.00 |
| CHEMBL355606 | — | — | 1 | 6.00 |
| CHEMBL441669 | — | — | 1 | 6.00 |
| CHEMBL1812545 | — | — | 1 | 5.70 |
| CHEMBL1812546 | — | — | 1 | 5.70 |
| CHEMBL435072 | — | — | 1 | 5.52 |
| CHEMBL1812531 | — | — | 1 | 5.52 |
| CHEMBL1812540 | — | — | 1 | 5.52 |
| CHEMBL1812543 | — | — | 1 | 5.52 |
| CHEMBL1812547 | — | — | 1 | 5.52 |
| CHEMBL168956 | — | — | 1 | 5.30 |
| CHEMBL1812554 | — | — | 1 | 5.22 |
| CHEMBL1812506 | — | — | 1 | 5.00 |
| CHEMBL1812544 | — | — | 1 | 5.00 |
| CHEMBL1812538 | — | — | 1 | 5.00 |
| CHEMBL1812535 | — | — | 1 | 5.00 |
| CHEMBL1812541 | — | — | 1 | 4.89 |
| CHEMBL1812498 | — | — | 1 | 4.75 |
| CHEMBL445966 | — | — | 1 | 4.75 |
| CHEMBL1812512 | — | — | 1 | 4.70 |
| CHEMBL166509 | — | — | 1 | 4.70 |
| CHEMBL1812520 | — | — | 1 | 4.70 |
| CHEMBL171548 | — | — | 1 | 4.70 |
| CHEMBL1812513 | — | — | 1 | 4.40 |
| CHEMBL1812515 | — | — | 1 | 4.40 |
| CHEMBL1812533 | — | — | 1 | 4.40 |
| CHEMBL176991 | — | — | 1 | 4.36 |
| CHEMBL1812526 | — | — | 1 | 4.30 |
| CHEMBL1812548 | — | — | 1 | 4.10 |
| CHEMBL1812553 | — | — | 1 | 4.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1812539 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL441669 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL355606 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1812545 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1812546 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL435072 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL1812531 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL1812540 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL1812543 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL1812547 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL168956 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL1812554 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL1812538 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1812506 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1812544 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1812535 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1812541 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL1812498 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL445966 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL1812512 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL166509 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL1812520 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL171548 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL1812533 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL1812513 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL1812515 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL176991 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL1812526 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL1812548 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL1812553 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL1812497 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL1812496 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL1812495 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL1812511 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL1812550 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL1812549 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL1812552 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL1812653 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL46724 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL1812654 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL1812551 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL1812542 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL1812656 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL1812530 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL1812536 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL1812655 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL1812658 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL1812657 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL1812659 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL1812537 | — | IC50 | > | 200000.0 | nM | - |