Assay Detail
Binding
CHEMBL1819636
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Inhibition of Streptococcus pneumoniae recombinant HMGR class II expressed in Escherichia coli using HMG-CoA as substrate
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Streptococcus pneumoniae |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Specific inhibitions of annonaceous acetogenins on class II 3-hydroxy-3-methylglutaryl coenzyme A reductase from Streptococcus pneumoniae.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 4.89 | 5.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1818440 | SQUAMOSTATIN A | — | 1 | 5.19 |
| CHEMBL606053 | ASIMICIN | — | 1 | 4.92 |
| CHEMBL68350 | BULLATALICIN | — | 1 | 4.75 |
| CHEMBL66691 | MOTRILIN | — | 1 | 4.69 |
| CHEMBL503 | LOVASTATIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1818440 | SQUAMOSTATIN A | Ki | = | 6450.0 | nM | 5.19 |
| CHEMBL606053 | ASIMICIN | Ki | = | 12170.0 | nM | 4.92 |
| CHEMBL68350 | BULLATALICIN | Ki | = | 17660.0 | nM | 4.75 |
| CHEMBL66691 | MOTRILIN | Ki | = | 20490.0 | nM | 4.69 |
| CHEMBL503 | LOVASTATIN | Ki | = | 116250.0 | nM | - |