Assay Detail
Binding
CHEMBL1819643
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]nisoxetine from human recombinant NET by scintillation proximity assay
44
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent noradrenaline transporter (CHEMBL222) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
1-Heteroaryl-6-(3,4-dichlorophenyl)-3-azabicyclo[4.1.0]heptane: further insights into a class of triple re-uptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 44 | 7.67 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1818445 | — | — | 2 | 9.40 |
| CHEMBL1818444 | — | — | 1 | 9.40 |
| CHEMBL608151 | — | — | 1 | 9.30 |
| CHEMBL1818448 | — | — | 1 | 9.20 |
| CHEMBL1818455 | — | — | 2 | 9.00 |
| CHEMBL296602 | INDATRALINE | 2.0 | 1 | 8.80 |
| CHEMBL1818454 | — | — | 1 | 8.80 |
| CHEMBL1818452 | — | — | 2 | 8.80 |
| CHEMBL1818451 | — | — | 2 | 8.50 |
| CHEMBL1173607 | — | — | 1 | 8.40 |
| CHEMBL1818443 | — | — | 1 | 8.20 |
| CHEMBL1173532 | GSK1360707 | 1.0 | 1 | 8.10 |
| CHEMBL1818463 | — | — | 1 | 8.00 |
| CHEMBL1818461 | — | — | 1 | 8.00 |
| CHEMBL1818456 | — | — | 1 | 8.00 |
| CHEMBL1818467 | — | — | 1 | 7.70 |
| CHEMBL1818468 | — | — | 1 | 7.70 |
| CHEMBL1818450 | — | — | 1 | 7.60 |
| CHEMBL1818543 | — | — | 2 | 7.60 |
| CHEMBL1818459 | — | — | 1 | 7.60 |
| CHEMBL1818460 | — | — | 1 | 7.60 |
| CHEMBL1818458 | — | — | 1 | 7.50 |
| CHEMBL1818449 | — | — | 1 | 7.50 |
| CHEMBL1818447 | — | — | 1 | 7.50 |
| CHEMBL1818465 | — | — | 1 | 7.50 |
| CHEMBL1818542 | — | — | 1 | 7.40 |
| CHEMBL1818464 | — | — | 1 | 7.40 |
| CHEMBL1818466 | — | — | 1 | 7.40 |
| CHEMBL1818446 | — | — | 1 | 7.40 |
| CHEMBL1818441 | — | — | 1 | 7.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1818445 | — | Ki | = | 0.3981 | nM | 9.40 |
| CHEMBL1818444 | — | Ki | = | 0.3981 | nM | 9.40 |
| CHEMBL608151 | — | Ki | = | 0.5012 | nM | 9.30 |
| CHEMBL1818448 | — | Ki | = | 0.631 | nM | 9.20 |
| CHEMBL1818455 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL296602 | INDATRALINE | Ki | = | 1.585 | nM | 8.80 |
| CHEMBL1818454 | — | Ki | = | 1.585 | nM | 8.80 |
| CHEMBL1818452 | — | Ki | = | 1.585 | nM | 8.80 |
| CHEMBL1818451 | — | Ki | = | 3.162 | nM | 8.50 |
| CHEMBL1173607 | — | Ki | = | 3.981 | nM | 8.40 |
| CHEMBL1818443 | — | Ki | = | 6.31 | nM | 8.20 |
| CHEMBL1173532 | GSK1360707 | Ki | = | 7.943 | nM | 8.10 |
| CHEMBL1818456 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL1818461 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL1818463 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL1818468 | — | Ki | = | 19.95 | nM | 7.70 |
| CHEMBL1818467 | — | Ki | = | 19.95 | nM | 7.70 |
| CHEMBL1818450 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL1818543 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL1818460 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL1818459 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL1818449 | — | Ki | = | 31.62 | nM | 7.50 |
| CHEMBL1818445 | — | Ki | = | 31.62 | nM | 7.50 |
| CHEMBL1818447 | — | Ki | = | 31.62 | nM | 7.50 |
| CHEMBL1818465 | — | Ki | = | 31.62 | nM | 7.50 |
| CHEMBL1818458 | — | Ki | = | 31.62 | nM | 7.50 |
| CHEMBL1818542 | — | Ki | = | 39.81 | nM | 7.40 |
| CHEMBL1818446 | — | Ki | = | 39.81 | nM | 7.40 |
| CHEMBL1818466 | — | Ki | = | 39.81 | nM | 7.40 |
| CHEMBL1818464 | — | Ki | = | 39.81 | nM | 7.40 |
| CHEMBL1818441 | — | Ki | = | 50.12 | nM | 7.30 |
| CHEMBL1818547 | — | Ki | = | 50.12 | nM | 7.30 |
| CHEMBL1818462 | — | Ki | = | 50.12 | nM | 7.30 |
| CHEMBL1818546 | — | Ki | = | 63.1 | nM | 7.20 |
| CHEMBL1818442 | AMITIFADINE HYDROCHLORIDE | Ki | = | 63.1 | nM | 7.20 |
| CHEMBL1818453 | — | Ki | = | 79.43 | nM | 7.10 |
| CHEMBL1818469 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL1818457 | — | Ki | = | 158.49 | nM | 6.80 |
| CHEMBL1818452 | — | Ki | = | 316.23 | nM | 6.50 |
| CHEMBL1818544 | — | Ki | = | 398.11 | nM | 6.40 |
| CHEMBL1818545 | — | Ki | = | 398.11 | nM | 6.40 |
| CHEMBL1818455 | — | Ki | = | 501.19 | nM | 6.30 |
| CHEMBL1818451 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL1818543 | — | Ki | = | 1584.89 | nM | 5.80 |