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Assay Detail

CHEMBL1819920

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Binding
Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate after 10 mins by fluorescent assay
ChEMBL ↗
46
Total Activities
46
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Bifunctional epoxide hydrolase 2 (CHEMBL2409) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

The structure-activity relationship of urea derivatives as anti-tuberculosis agents.
Brown JR, North EJ, Hurdle JG, Morisseau C, Scarborough JS, Sun D, Korduláková J, Scherman MS, Jones V, Grzegorzewicz A, Crew RM, Jackson M, McNeil MR, Lee RE.
Bioorg Med Chem (2011) 19 : 5585 -5595
PubMed 21840723 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 46 8.25 9.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1818408 — — 1 9.40
CHEMBL1818407 — — 1 9.40
CHEMBL1818404 — — 1 9.40
CHEMBL1817677 — — 1 9.40
CHEMBL1609005 — — 1 9.40
CHEMBL1818390 — — 1 9.40
CHEMBL1818389 — — 1 9.40
CHEMBL1818388 — — 1 9.40
CHEMBL1818387 — — 1 9.40
CHEMBL1818386 — — 1 9.40
CHEMBL1818385 — — 1 9.40
CHEMBL1818384 — — 1 9.40
CHEMBL1818395 — — 1 9.30
CHEMBL1818402 — — 1 9.30
CHEMBL1818401 — — 1 9.00
CHEMBL1818393 — — 1 8.96
CHEMBL1818391 — — 1 8.92
CHEMBL476614 — — 1 8.92
CHEMBL1818403 — — 1 8.80
CHEMBL1818409 — — 1 8.72
CHEMBL242255 — — 1 8.70
CHEMBL1818410 — — 1 8.43
CHEMBL1818397 — — 1 8.35
CHEMBL1818394 — — 1 8.35
CHEMBL1818411 — — 1 8.32
CHEMBL1818400 — — 1 8.19
CHEMBL1818420 — — 1 8.19
CHEMBL1818421 — — 1 7.92
CHEMBL1076347 TRICLOCARBAN 2.0 1 7.89
CHEMBL1818415 — — 1 7.84

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1818385 — IC50 = 0.4 nM 9.40
CHEMBL1818384 — IC50 = 0.4 nM 9.40
CHEMBL1818386 — IC50 = 0.4 nM 9.40
CHEMBL1818387 — IC50 = 0.4 nM 9.40
CHEMBL1818388 — IC50 = 0.4 nM 9.40
CHEMBL1818389 — IC50 = 0.4 nM 9.40
CHEMBL1609005 — IC50 = 0.4 nM 9.40
CHEMBL1818408 — IC50 = 0.4 nM 9.40
CHEMBL1818407 — IC50 = 0.4 nM 9.40
CHEMBL1818404 — IC50 = 0.4 nM 9.40
CHEMBL1817677 — IC50 = 0.4 nM 9.40
CHEMBL1818390 — IC50 = 0.4 nM 9.40
CHEMBL1818395 — IC50 = 0.5 nM 9.30
CHEMBL1818402 — IC50 = 0.5 nM 9.30
CHEMBL1818401 — IC50 = 1.0 nM 9.00
CHEMBL1818393 — IC50 = 1.1 nM 8.96
CHEMBL1818391 — IC50 = 1.2 nM 8.92
CHEMBL476614 — IC50 = 1.2 nM 8.92
CHEMBL1818403 — IC50 = 1.6 nM 8.80
CHEMBL1818409 — IC50 = 1.9 nM 8.72
CHEMBL242255 — IC50 = 2.0 nM 8.70
CHEMBL1818410 — IC50 = 3.7 nM 8.43
CHEMBL1818394 — IC50 = 4.5 nM 8.35
CHEMBL1818397 — IC50 = 4.5 nM 8.35
CHEMBL1818411 — IC50 = 4.8 nM 8.32
CHEMBL1818400 — IC50 = 6.4 nM 8.19
CHEMBL1818420 — IC50 = 6.5 nM 8.19
CHEMBL1818421 — IC50 = 12.0 nM 7.92
CHEMBL1076347 TRICLOCARBAN IC50 = 13.0 nM 7.89
CHEMBL1818415 — IC50 = 14.3 nM 7.84
CHEMBL1818396 — IC50 = 14.8 nM 7.83
CHEMBL1818406 — IC50 = 15.0 nM 7.82
CHEMBL1818405 — IC50 = 16.6 nM 7.78
CHEMBL1818398 — IC50 = 24.2 nM 7.62
CHEMBL1818413 — IC50 = 38.1 nM 7.42
CHEMBL1818392 — IC50 = 56.2 nM 7.25
CHEMBL1818399 — IC50 = 61.4 nM 7.21
CHEMBL1563200 — IC50 = 84.4 nM 7.07
CHEMBL1818419 — IC50 = 242.6 nM 6.62
CHEMBL1818418 — IC50 = 260.4 nM 6.58
CHEMBL1818417 — IC50 = 386.1 nM 6.41
CHEMBL354676 DIPHENYLUREA IC50 = 390.0 nM 6.41
CHEMBL1818412 — IC50 = 463.8 nM 6.33
CHEMBL1818416 — IC50 = 524.8 nM 6.28
CHEMBL1818414 — IC50 = 1838.1 nM 5.74
CHEMBL214920 TIOCARLIDE IC50 - — -