Assay Detail
Binding
CHEMBL1819932
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Mycobacterium tuberculosis recombinant EphB expressed in Escherichia coli BL21 using CMNPC as substrate after 30 mins by fluorescent assay relative to control
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium tuberculosis |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Epoxide hydrolase B (CHEMBL1795155) ↗| Type | SINGLE PROTEIN |
| Organism | Mycobacterium tuberculosis |
Publication
The structure-activity relationship of urea derivatives as anti-tuberculosis agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.44 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL354676 | DIPHENYLUREA | — | 1 | 7.72 |
| CHEMBL242255 | — | — | 1 | 6.89 |
| CHEMBL1076347 | TRICLOCARBAN | 2.0 | 1 | 6.66 |
| CHEMBL1818421 | — | — | 1 | 4.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL354676 | DIPHENYLUREA | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL242255 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1076347 | TRICLOCARBAN | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL1818421 | — | IC50 | = | 31600.0 | nM | 4.50 |