Assay Detail
Binding
CHEMBL1820132
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Inhibition of recombinant human renin using of DABCYL-c-Abu-IleHis-Pro-Phe-His-Leu-Val-Ile-His-Thr-EDANS as substrate after 60 to 360 mins by fluorescence method
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Biphenyl/diphenyl ether renin inhibitors: filling the S1 pocket of renin via the S3 pocket.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 8.00 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL496430 | — | — | 1 | 9.30 |
| CHEMBL1818070 | — | — | 1 | 9.15 |
| CHEMBL1818069 | — | — | 1 | 8.96 |
| CHEMBL1818063 | — | — | 1 | 8.96 |
| CHEMBL1818049 | — | — | 1 | 8.92 |
| CHEMBL1818055 | — | — | 1 | 8.85 |
| CHEMBL1818064 | — | — | 1 | 8.80 |
| CHEMBL1818062 | — | — | 1 | 8.80 |
| CHEMBL1818058 | — | — | 1 | 8.80 |
| CHEMBL1818067 | — | — | 1 | 8.74 |
| CHEMBL1818059 | — | — | 1 | 8.72 |
| CHEMBL1818065 | — | — | 1 | 8.68 |
| CHEMBL1818054 | — | — | 1 | 8.68 |
| CHEMBL1818071 | — | — | 1 | 8.64 |
| CHEMBL1818068 | — | — | 1 | 8.60 |
| CHEMBL1818047 | — | — | 1 | 8.57 |
| CHEMBL1818060 | — | — | 1 | 8.43 |
| CHEMBL1818066 | — | — | 1 | 8.42 |
| CHEMBL1818061 | — | — | 1 | 8.28 |
| CHEMBL1818056 | — | — | 1 | 8.15 |
| CHEMBL1818039 | — | — | 1 | 8.06 |
| CHEMBL1818052 | — | — | 1 | 8.00 |
| CHEMBL1818048 | — | — | 1 | 7.96 |
| CHEMBL1818046 | — | — | 1 | 7.72 |
| CHEMBL1818053 | — | — | 1 | 7.70 |
| CHEMBL1818051 | — | — | 1 | 7.64 |
| CHEMBL1818050 | — | — | 1 | 7.43 |
| CHEMBL1818041 | — | — | 1 | 6.90 |
| CHEMBL1818043 | — | — | 1 | 6.71 |
| CHEMBL1818040 | — | — | 1 | 6.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL496430 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL1818070 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL1818069 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL1818063 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL1818049 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL1818055 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL1818064 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL1818062 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL1818058 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL1818067 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL1818059 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL1818065 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL1818054 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL1818071 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL1818068 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL1818047 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL1818060 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL1818066 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL1818061 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL1818056 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL1818039 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL1818052 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1818048 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1818046 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1818053 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1818051 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL1818050 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL1818041 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL1818043 | — | IC50 | = | 195.0 | nM | 6.71 |
| CHEMBL1818040 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL1818038 | — | IC50 | = | 596.0 | nM | 6.22 |
| CHEMBL1818044 | — | IC50 | = | 1437.0 | nM | 5.84 |
| CHEMBL1818042 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL1818057 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL1818045 | — | IC50 | > | 5000.0 | nM | - |