Assay Detail
Binding
CHEMBL1820362
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of BACE1 expressed in baculovirus assessed as inhibition of amyloid beta-42 production after 60 mins by spectrofluorometric assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Multi-target strategy to address Alzheimer's disease: design, synthesis and biological evaluation of new tacrine-based dimers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.84 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1819180 | — | — | 1 | 6.40 |
| CHEMBL1819176 | — | — | 1 | 6.00 |
| CHEMBL32823 | — | — | 1 | 5.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1819180 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL1819176 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL32823 | — | IC50 | = | 7500.0 | nM | 5.12 |