Assay Detail
Binding
CHEMBL1820599
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Inhibition of diphenolase activity of mushroom tyrosinase using L-DOPA as substrate preincubated for 5 mins by spectroscopic method
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Agaricus bisporus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Refinement of arylthiosemicarbazone pharmacophore in inhibition of mushroom tyrosinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 4.84 | 5.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1818876 | — | — | 1 | 5.22 |
| CHEMBL1818886 | — | — | 1 | 5.16 |
| CHEMBL1818877 | — | — | 1 | 5.10 |
| CHEMBL1818874 | — | — | 1 | 5.05 |
| CHEMBL1818875 | — | — | 1 | 4.96 |
| CHEMBL1818888 | — | — | 1 | 4.96 |
| CHEMBL1818879 | — | — | 1 | 4.92 |
| CHEMBL393467 | — | — | 1 | 4.50 |
| CHEMBL25988 | — | — | 1 | 4.35 |
| CHEMBL215065 | — | — | 1 | 4.16 |
| CHEMBL1818878 | — | — | 1 | - |
| CHEMBL1818880 | — | — | 1 | - |
| CHEMBL1818881 | — | — | 1 | - |
| CHEMBL1818882 | — | — | 1 | - |
| CHEMBL1818883 | — | — | 1 | - |
| CHEMBL90808 | — | — | 1 | - |
| CHEMBL1818884 | — | — | 1 | - |
| CHEMBL1818885 | — | — | 1 | - |
| CHEMBL1276229 | — | — | 1 | - |
| CHEMBL1818887 | — | — | 1 | - |
| CHEMBL287556 | KOJIC ACID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1818876 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL1818886 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL1818877 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL1818874 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL1818875 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL1818888 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL1818879 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL393467 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL25988 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL215065 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL1818878 | — | IC50 | = | 1100000.0 | nM | - |
| CHEMBL1818880 | — | IC50 | = | 600000.0 | nM | - |
| CHEMBL1818881 | — | IC50 | > | 2000000.0 | nM | - |
| CHEMBL1818882 | — | IC50 | > | 2000000.0 | nM | - |
| CHEMBL1818883 | — | IC50 | = | 402000.0 | nM | - |
| CHEMBL90808 | — | IC50 | = | 1700000.0 | nM | - |
| CHEMBL1818884 | — | IC50 | > | 2000000.0 | nM | - |
| CHEMBL1818885 | — | IC50 | > | 2000000.0 | nM | - |
| CHEMBL1276229 | — | IC50 | = | 400000.0 | nM | - |
| CHEMBL1818887 | — | IC50 | > | 2000000.0 | nM | - |
| CHEMBL287556 | KOJIC ACID | IC50 | = | 102000.0 | nM | - |