Assay Detail
Functional
CHEMBL1820765
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity in human NCI-H460 cells in serum free medium at 50 nM after 12 hrs by Hoechst 33342/propidium iodide staining based fluorescence microscopy
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H460 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
C5'-Alkyl Substitution Effects on Digitoxigenin α-l-Glycoside Cancer Cytotoxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.89 | 7.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1651648 | — | — | 1 | 7.28 |
| CHEMBL1651649 | RAMNODIGIN | 2.0 | 1 | 7.28 |
| CHEMBL1818689 | — | — | 1 | 7.24 |
| CHEMBL1818693 | — | — | 1 | 7.06 |
| CHEMBL1818690 | — | — | 1 | 6.94 |
| CHEMBL1818691 | — | — | 1 | 6.89 |
| CHEMBL1818692 | — | — | 1 | 6.75 |
| CHEMBL1818812 | — | — | 1 | 6.34 |
| CHEMBL1818694 | — | — | 1 | 6.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1651648 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL1651649 | RAMNODIGIN | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL1818689 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL1818693 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL1818690 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL1818691 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1818692 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL1818812 | — | IC50 | = | 458.0 | nM | 6.34 |
| CHEMBL1818694 | — | IC50 | = | 533.0 | nM | 6.27 |