Assay Detail
Binding
CHEMBL1820877
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Inhibition of almond beta-glucosidase assessed as production of 4-methylumbelliferone using 4-methylumbelliferyl beta-D-glucoside as substrate by spectrophotometry
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Prunus dulcis |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Docking and SAR studies of D- and L-isofagomine isomers as human β-glucocerebrosidase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.20 | 6.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL206468 | AFEGOSTAT | 2.0 | 1 | 6.01 |
| CHEMBL1818433 | — | — | 1 | 5.50 |
| CHEMBL307429 | DUVOGLUSTAT | 2.0 | 1 | 4.10 |
| CHEMBL501385 | — | — | 1 | - |
| CHEMBL1818321 | — | — | 1 | - |
| CHEMBL1818434 | — | — | 1 | - |
| CHEMBL456583 | — | — | 1 | - |
| CHEMBL369297 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL206468 | AFEGOSTAT | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL1818433 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL307429 | DUVOGLUSTAT | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL501385 | — | IC50 | = | 236000.0 | nM | - |
| CHEMBL1818321 | — | IC50 | = | 443000.0 | nM | - |
| CHEMBL1818434 | — | IC50 | = | 983000.0 | nM | - |
| CHEMBL456583 | — | IC50 | = | 120000.0 | nM | - |
| CHEMBL369297 | — | IC50 | = | 980000.0 | nM | - |