Assay Detail
Binding
CHEMBL1820880
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human lysosome beta-glucosidase assessed as production of 4-methylumbelliferone using 4-methylumbelliferyl beta-D-glucoside as substrate by spectrophotometry
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Docking and SAR studies of D- and L-isofagomine isomers as human β-glucocerebrosidase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.51 | 7.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL206468 | AFEGOSTAT | 2.0 | 1 | 7.20 |
| CHEMBL501385 | — | — | 1 | 5.06 |
| CHEMBL1818433 | — | — | 1 | 4.27 |
| CHEMBL1818321 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL206468 | AFEGOSTAT | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL501385 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL1818433 | — | IC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL1818321 | — | IC50 | = | 113000.0 | nM | - |