Assay Detail
Binding
CHEMBL1820882
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Inhibition of bovine liver beta-galactosidase assessed as production of p-nitrophenol by spectrophotometry
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Docking and SAR studies of D- and L-isofagomine isomers as human β-glucocerebrosidase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.02 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL456583 | — | — | 1 | 5.52 |
| CHEMBL206468 | AFEGOSTAT | 2.0 | 1 | 5.44 |
| CHEMBL1818433 | — | — | 1 | 4.68 |
| CHEMBL108084 | FAGOMINE | — | 1 | 4.42 |
| CHEMBL501385 | — | — | 1 | - |
| CHEMBL1818432 | — | — | 1 | - |
| CHEMBL1818436 | — | — | 1 | - |
| CHEMBL369297 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL456583 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL206468 | AFEGOSTAT | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL1818433 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL108084 | FAGOMINE | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL501385 | — | IC50 | = | 821000.0 | nM | - |
| CHEMBL1818432 | — | IC50 | = | 389000.0 | nM | - |
| CHEMBL1818436 | — | IC50 | = | 960000.0 | nM | - |
| CHEMBL369297 | — | IC50 | = | 560000.0 | nM | - |