Assay Detail
Binding
CHEMBL1821030
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive inhibition of Bacillus subtilis LuxS preincubated for 15 mins by UV-vis spectrophotometric analysis
5
Total Activities
3
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bacillus subtilis |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
S-ribosylhomocysteine lyase (CHEMBL5171) ↗| Type | SINGLE PROTEIN |
| Organism | Bacillus subtilis (strain 168) |
Publication
Inhibition of LuxS by S-ribosylhomocysteine analogues containing a [4-aza]ribose ring.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kinact | 3 | - | - |
| Inhibition | 1 | - | - |
| IC50 | 1 | 4.22 | 4.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1818669 | — | — | 2 | 4.22 |
| CHEMBL1818667 | — | — | 2 | - |
| CHEMBL1818670 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1818669 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL1818667 | — | Inhibition | - | % | - | |
| CHEMBL1818667 | — | Kinact | = | 48.0 | uM | - |
| CHEMBL1818669 | — | Kinact | = | 3.5 | uM | - |
| CHEMBL1818670 | — | Kinact | = | 37.0 | uM | - |