Assay Detail
Binding
CHEMBL1821160
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Modulation of gamma-secretase expressed in CHO cells co-expressing human APP and wild type human presenilin-1 assessed as inhibition of amyloid beta42 production by ELISA
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
SAR studies of acidic dual γ-secretase/PPARγ modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 4.81 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1819479 | — | — | 1 | 5.92 |
| CHEMBL1819478 | — | — | 1 | 5.62 |
| CHEMBL1819480 | — | — | 1 | 5.57 |
| CHEMBL1819398 | — | — | 1 | 5.41 |
| CHEMBL1170264 | — | — | 1 | 5.29 |
| CHEMBL1171834 | — | — | 1 | 5.22 |
| CHEMBL1819397 | — | — | 1 | 4.81 |
| CHEMBL461883 | — | — | 1 | 4.64 |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 4.60 |
| CHEMBL1819392 | — | — | 1 | 4.49 |
| CHEMBL1817687 | — | — | 1 | 4.47 |
| CHEMBL1819390 | — | — | 1 | 4.42 |
| CHEMBL1819391 | — | — | 1 | 4.42 |
| CHEMBL1819393 | — | — | 1 | 4.10 |
| CHEMBL1819396 | — | — | 1 | 4.01 |
| CHEMBL1819394 | — | — | 1 | 4.00 |
| CHEMBL521 | IBUPROFEN | 4.0 | 1 | - |
| CHEMBL1316 | CARPROFEN | 4.0 | 1 | - |
| CHEMBL1819481 | — | — | 1 | - |
| CHEMBL1819482 | — | — | 1 | - |
| CHEMBL1819483 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1819479 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL1819478 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL1819480 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL1819398 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL1170264 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL1171834 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL1819397 | — | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL461883 | — | IC50 | = | 22800.0 | nM | 4.64 |
| CHEMBL6 | INDOMETHACIN | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL1819392 | — | IC50 | = | 32700.0 | nM | 4.49 |
| CHEMBL1817687 | — | IC50 | = | 33700.0 | nM | 4.47 |
| CHEMBL1819390 | — | IC50 | = | 38400.0 | nM | 4.42 |
| CHEMBL1819391 | — | IC50 | = | 37900.0 | nM | 4.42 |
| CHEMBL1819393 | — | IC50 | = | 79000.0 | nM | 4.10 |
| CHEMBL1819396 | — | IC50 | = | 97000.0 | nM | 4.01 |
| CHEMBL1819394 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL521 | IBUPROFEN | IC50 | = | 200000.0 | nM | - |
| CHEMBL1316 | CARPROFEN | IC50 | = | 305000.0 | nM | - |
| CHEMBL1819481 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL1819482 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL1819483 | — | IC50 | > | 40000.0 | nM | - |