Assay Detail
Binding
CHEMBL1821165
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant COX-2 assessed as residual activity by measuring formation of 12-HHT from arachidonic acid by HPLC analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
SAR studies of acidic dual γ-secretase/PPARγ modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.01 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 8.00 |
| CHEMBL1316 | CARPROFEN | 4.0 | 1 | 6.99 |
| CHEMBL1171834 | — | — | 1 | 4.96 |
| CHEMBL521 | IBUPROFEN | 4.0 | 1 | 4.10 |
| CHEMBL461883 | — | — | 1 | - |
| CHEMBL1170264 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1316 | CARPROFEN | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL1171834 | — | IC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL521 | IBUPROFEN | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL461883 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL1170264 | — | IC50 | > | 40000.0 | nM | - |