Assay Detail
Binding
CHEMBL1821204
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Inhibition of human N-terminal His-tagged non-phosphorylated VEGFR2 preincubated for 120 mins in presence of ATP by AlphaScreen analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Biochemical characterization of a novel type-II VEGFR2 kinase inhibitor: comparison of binding to non-phosphorylated and phosphorylated VEGFR2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 9.37 | 10.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1254007 | — | — | 1 | 10.48 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 9.80 |
| CHEMBL388978 | STAUROSPORINE | — | 1 | 8.92 |
| CHEMBL535 | SUNITINIB | 4.0 | 1 | 8.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1254007 | — | IC50 | = | 0.033 | nM | 10.48 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 0.16 | nM | 9.80 |
| CHEMBL388978 | STAUROSPORINE | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL535 | SUNITINIB | IC50 | = | 5.5 | nM | 8.26 |