Assay Detail
Binding
CHEMBL1821211
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Inhibition of human N-terminal His-tagged non-phosphorylated VEGFR2 after 60 mins by activity based 100 fold dilution assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Biochemical characterization of a novel type-II VEGFR2 kinase inhibitor: comparison of binding to non-phosphorylated and phosphorylated VEGFR2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 10.65 | 10.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 10.68 |
| CHEMBL1254007 | — | — | 1 | 10.62 |
| CHEMBL535 | SUNITINIB | 4.0 | 1 | - |
| CHEMBL388978 | STAUROSPORINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1336 | SORAFENIB | Ki | = | 0.021 | nM | 10.68 |
| CHEMBL1254007 | — | Ki | = | 0.024 | nM | 10.62 |
| CHEMBL535 | SUNITINIB | Ki | - | — | - | |
| CHEMBL388978 | STAUROSPORINE | Ki | - | — | - |