Assay Detail
Binding
CHEMBL1821328
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human cloned carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Carbonic anhydrase inhibitors. Synthesis, molecular structures, and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with novel 3-pyridinesulfonamide derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 7.16 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 8.10 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.92 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 7.85 |
| CHEMBL77517 | INDISULAM | 2.0 | 1 | 7.82 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 7.42 |
| CHEMBL1242890 | — | — | 1 | 7.30 |
| CHEMBL1817908 | — | — | 1 | 7.26 |
| CHEMBL1817672 | — | — | 1 | 7.05 |
| CHEMBL1817905 | — | — | 1 | 7.01 |
| CHEMBL1817901 | — | — | 1 | 6.99 |
| CHEMBL1817904 | — | — | 1 | 6.83 |
| CHEMBL1817906 | — | — | 1 | 6.66 |
| CHEMBL1817902 | — | — | 1 | 6.47 |
| CHEMBL1817903 | — | — | 1 | 6.41 |
| CHEMBL1817907 | — | — | 1 | 6.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL77517 | INDISULAM | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL1242890 | — | Ki | = | 50.5 | nM | 7.30 |
| CHEMBL1817908 | — | Ki | = | 54.6 | nM | 7.26 |
| CHEMBL1817672 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL1817905 | — | Ki | = | 98.3 | nM | 7.01 |
| CHEMBL1817901 | — | Ki | = | 102.0 | nM | 6.99 |
| CHEMBL1817904 | — | Ki | = | 149.0 | nM | 6.83 |
| CHEMBL1817906 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL1817902 | — | Ki | = | 336.0 | nM | 6.47 |
| CHEMBL1817903 | — | Ki | = | 391.0 | nM | 6.41 |
| CHEMBL1817907 | — | Ki | = | 487.0 | nM | 6.31 |