Assay Detail
Binding
CHEMBL1821329
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human cloned carbonic anhydrase 9 catalytic domain preincubated for 15 mins by stopped flow CO2 hydration assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Carbonic anhydrase inhibitors. Synthesis, molecular structures, and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with novel 3-pyridinesulfonamide derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 7.86 | 8.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1242890 | — | — | 1 | 8.28 |
| CHEMBL1817902 | — | — | 1 | 8.13 |
| CHEMBL1817901 | — | — | 1 | 8.12 |
| CHEMBL1817906 | — | — | 1 | 8.06 |
| CHEMBL1817908 | — | — | 1 | 8.05 |
| CHEMBL1817904 | — | — | 1 | 8.05 |
| CHEMBL1817903 | — | — | 1 | 8.00 |
| CHEMBL1817907 | — | — | 1 | 7.99 |
| CHEMBL1817672 | — | — | 1 | 7.87 |
| CHEMBL1817905 | — | — | 1 | 7.74 |
| CHEMBL77517 | INDISULAM | 2.0 | 1 | 7.62 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.60 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 7.57 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 7.47 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 7.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1242890 | — | Ki | = | 5.2 | nM | 8.28 |
| CHEMBL1817902 | — | Ki | = | 7.4 | nM | 8.13 |
| CHEMBL1817901 | — | Ki | = | 7.6 | nM | 8.12 |
| CHEMBL1817906 | — | Ki | = | 8.7 | nM | 8.06 |
| CHEMBL1817908 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL1817904 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL1817903 | — | Ki | = | 10.1 | nM | 8.00 |
| CHEMBL1817907 | — | Ki | = | 10.2 | nM | 7.99 |
| CHEMBL1817672 | — | Ki | = | 13.5 | nM | 7.87 |
| CHEMBL1817905 | — | Ki | = | 18.3 | nM | 7.74 |
| CHEMBL77517 | INDISULAM | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 50.0 | nM | 7.30 |