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Assay Detail

CHEMBL1825399

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of goat brain tubulin polymerization assessed as turbidity by UV spectrophotometry
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Capra hircus
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Curcumin recognizes a unique binding site of tubulin.
Chakraborti S, Das L, Kapoor N, Das A, Dwivedi V, Poddar A, Chakraborti G, Janik M, Basu G, Panda D, Chakrabarti P, Surolia A, Bhattacharyya B.
J Med Chem (2011) 54 : 6183 -6196
PubMed 21830815 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 8 4.53 4.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL428441 1 4.80
CHEMBL140 CURCUMIN 3.0 1 4.70
CHEMBL180239 CURCUMIN PYRAZOLE 1 4.64
CHEMBL181529 1 4.58
CHEMBL258739 1 4.47
CHEMBL258632 1 4.44
CHEMBL410334 1 4.42
CHEMBL261297 1 4.22

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL428441 IC50 = 16000.0 nM 4.80
CHEMBL140 CURCUMIN IC50 = 20000.0 nM 4.70
CHEMBL180239 CURCUMIN PYRAZOLE IC50 = 23000.0 nM 4.64
CHEMBL181529 IC50 = 26000.0 nM 4.58
CHEMBL258739 IC50 = 34000.0 nM 4.47
CHEMBL258632 IC50 = 36000.0 nM 4.44
CHEMBL410334 IC50 = 38000.0 nM 4.42
CHEMBL261297 IC50 = 60000.0 nM 4.22