Assay Detail
Functional
CHEMBL1825447
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Cytotoxicity against human LAMA-84 cells assessed as cell viability after 48 hrs by alamar blue assay
11
Total Activities
8
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LAMA-84 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Selective cytotoxicity of oxysterols through structural modulation on rings A and B. Synthesis, in vitro evaluation, and SAR.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.42 | 6.13 |
| Inhibition | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.13 |
| CHEMBL1825076 | — | — | 1 | 5.41 |
| CHEMBL1824839 | — | — | 1 | 5.37 |
| CHEMBL497834 | — | — | 1 | 5.37 |
| CHEMBL1278089 | CHOLESTAN-3beta,5alpha,6beta-TRIOL | — | 1 | 5.30 |
| CHEMBL1824836 | — | — | 2 | 5.29 |
| CHEMBL1825079 | — | — | 2 | 5.29 |
| CHEMBL1825088 | — | — | 2 | 5.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL1825076 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL1824839 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL497834 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL1278089 | CHOLESTAN-3beta,5alpha,6beta-TRIOL | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL1824836 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL1825079 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL1825088 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL1824836 | — | Inhibition | - | % | - | |
| CHEMBL1825079 | — | Inhibition | - | % | - | |
| CHEMBL1825088 | — | Inhibition | - | % | - |