Assay Detail
Functional
CHEMBL1825451
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Cytotoxicity against human A549 cells assessed as cell viability after 48 hrs by alamar blue assay
12
Total Activities
10
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Selective cytotoxicity of oxysterols through structural modulation on rings A and B. Synthesis, in vitro evaluation, and SAR.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.92 | 6.02 |
| Inhibition | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.02 |
| CHEMBL1825076 | — | — | 1 | 4.88 |
| CHEMBL497834 | — | — | 1 | 4.87 |
| CHEMBL1825088 | — | — | 2 | 4.86 |
| CHEMBL1825073 | — | — | 1 | 4.84 |
| CHEMBL1825074 | — | — | 1 | 4.82 |
| CHEMBL1825079 | — | — | 2 | 4.76 |
| CHEMBL1278089 | CHOLESTAN-3beta,5alpha,6beta-TRIOL | — | 1 | 4.75 |
| CHEMBL1824835 | — | — | 1 | 4.50 |
| CHEMBL1824836 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL1825076 | — | IC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL497834 | — | IC50 | = | 13600.0 | nM | 4.87 |
| CHEMBL1825088 | — | IC50 | = | 13900.0 | nM | 4.86 |
| CHEMBL1825073 | — | IC50 | = | 14500.0 | nM | 4.84 |
| CHEMBL1825074 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL1825079 | — | IC50 | = | 17300.0 | nM | 4.76 |
| CHEMBL1278089 | CHOLESTAN-3beta,5alpha,6beta-TRIOL | IC50 | = | 17900.0 | nM | 4.75 |
| CHEMBL1824835 | — | IC50 | = | 31800.0 | nM | 4.50 |
| CHEMBL1824836 | — | Inhibition | - | % | - | |
| CHEMBL1825079 | — | Inhibition | - | % | - | |
| CHEMBL1825088 | — | Inhibition | - | % | - |