Assay Detail
Binding
CHEMBL1825458
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Aurora kinase A assessed as phosphorylation of Lats2 substrate at 0.017 to 30 nM by FRET assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of pyrazolopyrimidine-sulfonamides as potent multiple-mitotic kinase (MMK) inhibitors (part I).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.48 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1825090 | — | — | 1 | 8.30 |
| CHEMBL1825092 | — | — | 1 | 8.30 |
| CHEMBL1825091 | — | — | 1 | 8.22 |
| CHEMBL1825095 | — | — | 1 | 8.05 |
| CHEMBL1821761 | — | — | 1 | 7.89 |
| CHEMBL1825089 | — | — | 1 | 7.85 |
| CHEMBL1825096 | — | — | 1 | 7.77 |
| CHEMBL1825093 | — | — | 1 | 7.70 |
| CHEMBL1825094 | — | — | 1 | 7.52 |
| CHEMBL1825102 | — | — | 1 | 7.02 |
| CHEMBL1825100 | — | — | 1 | 6.96 |
| CHEMBL1825097 | — | — | 1 | 6.82 |
| CHEMBL1825101 | — | — | 1 | 6.75 |
| CHEMBL1825099 | — | — | 1 | 6.58 |
| CHEMBL1825098 | — | — | 1 | 6.46 |
| CHEMBL1825103 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1825090 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1825092 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1825091 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1825095 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1821761 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1825089 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1825096 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL1825093 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1825094 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1825102 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL1825100 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1825097 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL1825101 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL1825099 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL1825098 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL1825103 | — | IC50 | > | 10000.0 | nM | - |