Assay Detail
Binding
CHEMBL1825581
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human c-RAF
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
RAF proto-oncogene serine/threonine-protein kinase (CHEMBL1906) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Indolin-2-one p38α inhibitors II: Lead optimisation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.95 | 6.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1825158 | — | — | 1 | 6.98 |
| CHEMBL1825147 | — | — | 1 | 6.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1825158 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL1825147 | — | IC50 | = | 120.0 | nM | 6.92 |