Assay Detail
Binding
CHEMBL1825599
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Inhibition of recombinant JNK2 using ser73 of c-jun as substrate preincubated for 15 mins measured after 60 mins by TR-FRET assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 7.44 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1822146 | — | — | 1 | 8.30 |
| CHEMBL1822140 | — | — | 1 | 8.10 |
| CHEMBL1822152 | — | — | 1 | 8.00 |
| CHEMBL1822151 | — | — | 1 | 8.00 |
| CHEMBL1822149 | — | — | 1 | 7.92 |
| CHEMBL1822305 | — | — | 1 | 7.89 |
| CHEMBL1822145 | — | — | 1 | 7.82 |
| CHEMBL1822309 | — | — | 1 | 7.77 |
| CHEMBL1822139 | — | — | 1 | 7.75 |
| CHEMBL1822141 | — | — | 1 | 7.68 |
| CHEMBL1822147 | — | — | 1 | 7.68 |
| CHEMBL1822137 | — | — | 1 | 7.62 |
| CHEMBL1822307 | — | — | 1 | 7.54 |
| CHEMBL1822138 | — | — | 1 | 7.50 |
| CHEMBL1822144 | — | — | 1 | 7.44 |
| CHEMBL1822142 | — | — | 1 | 7.42 |
| CHEMBL1682013 | — | — | 1 | 7.38 |
| CHEMBL1822308 | — | — | 1 | 7.28 |
| CHEMBL1822306 | — | — | 1 | 7.21 |
| CHEMBL1822153 | — | — | 1 | 7.18 |
| CHEMBL1822132 | — | — | 1 | 7.17 |
| CHEMBL1822150 | — | — | 1 | 7.17 |
| CHEMBL1822143 | — | — | 1 | 7.13 |
| CHEMBL1822133 | — | — | 1 | 7.04 |
| CHEMBL1822134 | — | — | 1 | 6.85 |
| CHEMBL1822154 | — | — | 1 | 6.84 |
| CHEMBL1822135 | — | — | 1 | 6.79 |
| CHEMBL1822148 | — | — | 1 | 6.71 |
| CHEMBL1822136 | — | — | 1 | 6.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1822146 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1822140 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1822152 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1822151 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1822149 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1822305 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1822145 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1822309 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL1822139 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1822141 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL1822147 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL1822137 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL1822307 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL1822138 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL1822144 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL1822142 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL1682013 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL1822308 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL1822306 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL1822153 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL1822132 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL1822150 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL1822143 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL1822133 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL1822134 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL1822154 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL1822135 | — | IC50 | = | 164.0 | nM | 6.79 |
| CHEMBL1822148 | — | IC50 | = | 193.0 | nM | 6.71 |
| CHEMBL1822136 | — | IC50 | = | 337.0 | nM | 6.47 |