Assay Detail
Functional
CHEMBL1825692
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Neuroprotective activity in human cerebral cortical neurons assessed as reversal of amyloid beta-induced neuronal damage after 2 to 3 days
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Cortical neurone |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 1 | 5.54 | 5.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1822146 | — | — | 1 | 5.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1822146 | — | EC50 | = | 2900.0 | nM | 5.54 |