Assay Detail
Functional
CHEMBL1825955
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Cytotoxicity against human A549 cells expressing Wnt2 after 24 to 72 hrs by MTS assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A novel 3-arylethynyl-substituted pyrido[2,3,-b]pyrazine derivatives and pharmacophore model as Wnt2/β-catenin pathway inhibitors in non-small-cell lung cancer cell lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.90 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1822335 | — | — | 1 | 6.70 |
| CHEMBL1822340 | — | — | 1 | 6.46 |
| CHEMBL1822341 | — | — | 1 | 6.24 |
| CHEMBL1822343 | — | — | 1 | 6.19 |
| CHEMBL1822336 | — | — | 1 | 6.14 |
| CHEMBL1822337 | — | — | 1 | 6.14 |
| CHEMBL1822338 | — | — | 1 | 5.76 |
| CHEMBL1822342 | — | — | 1 | 5.72 |
| CHEMBL1822345 | — | — | 1 | 5.71 |
| CHEMBL1822346 | — | — | 1 | 5.61 |
| CHEMBL1822347 | — | — | 1 | 5.54 |
| CHEMBL1822344 | — | — | 1 | 5.53 |
| CHEMBL460433 | CALPHOSTIN C | — | 1 | 5.50 |
| CHEMBL1822339 | — | — | 1 | 5.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1822335 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1822340 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL1822341 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL1822343 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL1822336 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL1822337 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL1822338 | — | IC50 | = | 1720.0 | nM | 5.76 |
| CHEMBL1822342 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL1822345 | — | IC50 | = | 1940.0 | nM | 5.71 |
| CHEMBL1822346 | — | IC50 | = | 2450.0 | nM | 5.61 |
| CHEMBL1822347 | — | IC50 | = | 2890.0 | nM | 5.54 |
| CHEMBL1822344 | — | IC50 | = | 2950.0 | nM | 5.53 |
| CHEMBL460433 | CALPHOSTIN C | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL1822339 | — | IC50 | = | 4000.0 | nM | 5.40 |