Assay Detail
Binding
CHEMBL1826105
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-DTG from sigma 2 receptor from rat liver in presence of pantazocine
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Fluorescent derivatives of σ receptor ligand 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) as a tool for uptake and cellular localization studies in pancreatic tumor cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.31 | 9.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53325 | — | — | 1 | 9.17 |
| CHEMBL1822597 | — | — | 1 | 7.97 |
| CHEMBL1822599 | — | — | 1 | 7.68 |
| CHEMBL282433 | DITOLYLGUANIDINE | — | 1 | 7.61 |
| CHEMBL1822600 | — | — | 1 | 7.59 |
| CHEMBL1822598 | — | — | 1 | 7.41 |
| CHEMBL1822595 | — | — | 1 | 5.76 |
| CHEMBL1822596 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53325 | — | Ki | = | 0.68 | nM | 9.17 |
| CHEMBL1822597 | — | Ki | = | 10.8 | nM | 7.97 |
| CHEMBL1822599 | — | Ki | = | 20.8 | nM | 7.68 |
| CHEMBL282433 | DITOLYLGUANIDINE | Ki | = | 24.6 | nM | 7.61 |
| CHEMBL1822600 | — | Ki | = | 25.7 | nM | 7.59 |
| CHEMBL1822598 | — | Ki | = | 39.3 | nM | 7.41 |
| CHEMBL1822595 | — | Ki | = | 1720.0 | nM | 5.76 |
| CHEMBL1822596 | — | Ki | = | 5020.0 | nM | 5.30 |