Assay Detail
Functional
CHEMBL1826423
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Antimalarial activity against Plasmodium falciparum infected in A-positive human erythrocytes assessed as [3H]-hypoxanthine uptake after 24 hrs by liquid scintillation counter
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Potent antimalarial 4-pyridones with improved physico-chemical properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.48 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1649745 | — | — | 1 | 5.70 |
| CHEMBL1823624 | — | — | 1 | 5.52 |
| CHEMBL469011 | — | — | 1 | 5.52 |
| CHEMBL467584 | — | — | 1 | 5.16 |
| CHEMBL1823416 | — | — | 1 | - |
| CHEMBL1823621 | — | — | 1 | - |
| CHEMBL1823415 | — | — | 1 | - |
| CHEMBL1823622 | — | — | 1 | - |
| CHEMBL1823623 | — | — | 1 | - |
| CHEMBL1823625 | — | — | 1 | - |
| CHEMBL1823626 | — | — | 1 | - |
| CHEMBL1823627 | — | — | 1 | - |
| CHEMBL1823628 | — | — | 1 | - |
| CHEMBL1823629 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1649745 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1823624 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL469011 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL467584 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL1823416 | — | IC50 | = | 130000.0 | nM | - |
| CHEMBL1823621 | — | IC50 | = | 120000.0 | nM | - |
| CHEMBL1823415 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL1823622 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL1823623 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL1823625 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL1823626 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL1823627 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL1823628 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL1823629 | — | IC50 | > | 250000.0 | nM | - |