Assay Detail
Binding
CHEMBL1826563
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Competitive inhibition of Mycobacterium tuberculosis DHQ2
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium tuberculosis |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
3-dehydroquinate dehydratase (CHEMBL3345) ↗| Type | SINGLE PROTEIN |
| Organism | Mycobacterium tuberculosis |
Publication
A prodrug approach for improving antituberculosis activity of potent Mycobacterium tuberculosis type II dehydroquinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 6.75 | 7.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL567563 | — | — | 1 | 7.55 |
| CHEMBL576247 | — | — | 1 | 7.51 |
| CHEMBL1823560 | — | — | 1 | 7.46 |
| CHEMBL1823561 | — | — | 1 | 7.46 |
| CHEMBL1823559 | — | — | 1 | 7.41 |
| CHEMBL1823562 | — | — | 1 | 7.40 |
| CHEMBL567564 | — | — | 1 | 7.37 |
| CHEMBL188524 | — | — | 1 | 7.27 |
| CHEMBL1823571 | — | — | 1 | 7.23 |
| CHEMBL1823558 | — | — | 1 | 6.92 |
| CHEMBL1823563 | — | — | 1 | 6.73 |
| CHEMBL567136 | — | — | 1 | 6.63 |
| CHEMBL1823569 | — | — | 1 | 6.60 |
| CHEMBL1823557 | — | — | 1 | 6.60 |
| CHEMBL1823565 | — | — | 1 | 6.36 |
| CHEMBL1823570 | — | — | 1 | 6.06 |
| CHEMBL1823564 | — | — | 1 | 5.96 |
| CHEMBL1823568 | — | — | 1 | 5.91 |
| CHEMBL1823567 | — | — | 1 | 5.29 |
| CHEMBL1823566 | — | — | 1 | 5.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL567563 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL576247 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL1823560 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL1823561 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL1823559 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL1823562 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL567564 | — | Ki | = | 42.5 | nM | 7.37 |
| CHEMBL188524 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL1823571 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL1823558 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL1823563 | — | Ki | = | 188.0 | nM | 6.73 |
| CHEMBL567136 | — | Ki | = | 235.0 | nM | 6.63 |
| CHEMBL1823569 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL1823557 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL1823565 | — | Ki | = | 440.0 | nM | 6.36 |
| CHEMBL1823570 | — | Ki | = | 870.0 | nM | 6.06 |
| CHEMBL1823564 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL1823568 | — | Ki | = | 1240.0 | nM | 5.91 |
| CHEMBL1823567 | — | Ki | = | 5100.0 | nM | 5.29 |
| CHEMBL1823566 | — | Ki | = | 6000.0 | nM | 5.22 |