Assay Detail
Binding
CHEMBL1826889
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]histamine from human H4R receptor expressed in HEK293 cells at 10 uM after 1.5 hrs by liquid scintillation counting
9
Total Activities
9
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Fragment library screening reveals remarkable similarities between the G protein-coupled receptor histamine H₄ and the ion channel serotonin 5-HT₃A.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.92 | 8.20 |
| pKi | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL492884 | — | — | 1 | 8.20 |
| CHEMBL414183 | — | — | 1 | 7.20 |
| CHEMBL78838 | — | — | 1 | 7.00 |
| CHEMBL1824046 | — | — | 1 | 6.70 |
| CHEMBL17740 | — | — | 1 | 6.20 |
| CHEMBL260565 | — | — | 1 | 6.20 |
| CHEMBL27453 | — | — | 1 | - |
| CHEMBL148204 | — | — | 1 | - |
| CHEMBL1824047 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL492884 | — | Ki | = | 6.31 | nM | 8.20 |
| CHEMBL414183 | — | Ki | = | 63.1 | nM | 7.20 |
| CHEMBL78838 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL1824046 | — | Ki | = | 199.53 | nM | 6.70 |
| CHEMBL17740 | — | Ki | = | 630.96 | nM | 6.20 |
| CHEMBL260565 | — | Ki | = | 630.96 | nM | 6.20 |
| CHEMBL27453 | — | pKi | - | — | - | |
| CHEMBL148204 | — | pKi | - | — | - | |
| CHEMBL1824047 | — | pKi | - | — | - |