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Assay Detail

CHEMBL1827052

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antifungal activity against Candida albicans isolate CaCi-2 after 48 hrs by Almar blue fluorimetry
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Candida albicans
Confidence 1 — Organism
Curated By Autocuration

Target

Candida albicans (CHEMBL366)
Type ORGANISM
Organism Candida albicans

Publication

Piperazinyl quinolines as chemosensitizers to increase fluconazole susceptibility of Candida albicans clinical isolates.
Youngsaye W, Vincent B, Hartland CL, Morgan BJ, Buhrlage SJ, Johnston S, Bittker JA, MacPherson L, Dandapani S, Palmer M, Whitesell L, Lindquist S, Schreiber SL, Munoz B.
Bioorg Med Chem Lett (2011) 21 : 5502 -5505
PubMed 21802942 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 4.82 4.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1360505 1 4.82
CHEMBL1256729 1 4.82
CHEMBL1822266 1 4.82
CHEMBL1822267 1 4.82
CHEMBL1822268 1 4.82
CHEMBL1822269 1 4.82
CHEMBL1822270 1 4.82
CHEMBL1822271 1 4.82
CHEMBL1822272 1 4.82
CHEMBL1822273 1 4.82
CHEMBL1822274 1 4.82
CHEMBL1585578 1 4.82
CHEMBL1822275 1 4.82
CHEMBL1822276 1 4.82
CHEMBL1822277 1 4.82
CHEMBL1822278 1 4.82

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1360505 IC50 = 15000.0 nM 4.82
CHEMBL1256729 IC50 = 15000.0 nM 4.82
CHEMBL1822266 IC50 = 15000.0 nM 4.82
CHEMBL1822267 IC50 = 15000.0 nM 4.82
CHEMBL1822268 IC50 = 15000.0 nM 4.82
CHEMBL1822269 IC50 = 15000.0 nM 4.82
CHEMBL1822270 IC50 = 15000.0 nM 4.82
CHEMBL1822271 IC50 = 15000.0 nM 4.82
CHEMBL1822272 IC50 = 15000.0 nM 4.82
CHEMBL1822273 IC50 = 15000.0 nM 4.82
CHEMBL1822274 IC50 = 15000.0 nM 4.82
CHEMBL1585578 IC50 = 15000.0 nM 4.82
CHEMBL1822275 IC50 = 15000.0 nM 4.82
CHEMBL1822276 IC50 = 15000.0 nM 4.82
CHEMBL1822277 IC50 = 15000.0 nM 4.82
CHEMBL1822278 IC50 = 15000.0 nM 4.82