Assay Detail
Binding
CHEMBL1827218
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Binding affinity to Aurora A kinase catalytic domain by competitive binding assay
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Novel series of pyrrolotriazine analogs as highly potent pan-Aurora kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 37 | 7.76 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL572878 | TOZASERTIB | 2.0 | 1 | 8.40 |
| CHEMBL1822648 | — | — | 1 | 8.30 |
| CHEMBL1822651 | — | — | 1 | 8.30 |
| CHEMBL1822649 | — | — | 1 | 8.22 |
| CHEMBL1822661 | — | — | 1 | 8.15 |
| CHEMBL1822487 | — | — | 1 | 8.15 |
| CHEMBL1822490 | — | — | 1 | 8.15 |
| CHEMBL1822653 | — | — | 1 | 8.15 |
| CHEMBL1822652 | — | — | 1 | 8.10 |
| CHEMBL1822650 | — | — | 1 | 8.10 |
| CHEMBL1822638 | — | — | 1 | 8.10 |
| CHEMBL1822640 | — | — | 1 | 8.10 |
| CHEMBL1822655 | — | — | 1 | 8.05 |
| CHEMBL1822637 | — | — | 1 | 8.05 |
| CHEMBL1822656 | — | — | 1 | 8.00 |
| CHEMBL1822489 | — | — | 1 | 8.00 |
| CHEMBL1822654 | — | — | 1 | 7.96 |
| CHEMBL1822647 | — | — | 1 | 7.92 |
| CHEMBL1822485 | — | — | 1 | 7.92 |
| CHEMBL1822659 | — | — | 1 | 7.89 |
| CHEMBL1822495 | — | — | 1 | 7.85 |
| CHEMBL1822658 | — | — | 1 | 7.82 |
| CHEMBL1822639 | — | — | 1 | 7.82 |
| CHEMBL1822641 | — | — | 1 | 7.77 |
| CHEMBL1822657 | — | — | 1 | 7.77 |
| CHEMBL1822488 | — | — | 1 | 7.64 |
| CHEMBL1822660 | — | — | 1 | 7.58 |
| CHEMBL1822494 | — | — | 1 | 7.51 |
| CHEMBL1822491 | — | — | 1 | 7.50 |
| CHEMBL1822486 | — | — | 1 | 7.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL572878 | TOZASERTIB | Kd | = | 4.0 | nM | 8.40 |
| CHEMBL1822648 | — | Kd | = | 5.0 | nM | 8.30 |
| CHEMBL1822651 | — | Kd | = | 5.0 | nM | 8.30 |
| CHEMBL1822649 | — | Kd | = | 6.0 | nM | 8.22 |
| CHEMBL1822661 | — | Kd | = | 7.0 | nM | 8.15 |
| CHEMBL1822487 | — | Kd | = | 7.0 | nM | 8.15 |
| CHEMBL1822490 | — | Kd | = | 7.0 | nM | 8.15 |
| CHEMBL1822653 | — | Kd | = | 7.0 | nM | 8.15 |
| CHEMBL1822652 | — | Kd | = | 8.0 | nM | 8.10 |
| CHEMBL1822650 | — | Kd | = | 8.0 | nM | 8.10 |
| CHEMBL1822638 | — | Kd | = | 8.0 | nM | 8.10 |
| CHEMBL1822640 | — | Kd | = | 8.0 | nM | 8.10 |
| CHEMBL1822655 | — | Kd | = | 9.0 | nM | 8.05 |
| CHEMBL1822637 | — | Kd | = | 9.0 | nM | 8.05 |
| CHEMBL1822489 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL1822656 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL1822654 | — | Kd | = | 11.0 | nM | 7.96 |
| CHEMBL1822485 | — | Kd | = | 12.0 | nM | 7.92 |
| CHEMBL1822647 | — | Kd | = | 12.0 | nM | 7.92 |
| CHEMBL1822659 | — | Kd | = | 13.0 | nM | 7.89 |
| CHEMBL1822495 | — | Kd | = | 14.0 | nM | 7.85 |
| CHEMBL1822658 | — | Kd | = | 15.0 | nM | 7.82 |
| CHEMBL1822639 | — | Kd | = | 15.0 | nM | 7.82 |
| CHEMBL1822641 | — | Kd | = | 17.0 | nM | 7.77 |
| CHEMBL1822657 | — | Kd | = | 17.0 | nM | 7.77 |
| CHEMBL1822488 | — | Kd | = | 23.0 | nM | 7.64 |
| CHEMBL1822660 | — | Kd | = | 26.0 | nM | 7.58 |
| CHEMBL1822494 | — | Kd | = | 31.0 | nM | 7.51 |
| CHEMBL1822491 | — | Kd | = | 32.0 | nM | 7.50 |
| CHEMBL1822486 | — | Kd | = | 38.0 | nM | 7.42 |
| CHEMBL1822642 | — | Kd | = | 53.0 | nM | 7.28 |
| CHEMBL1822645 | — | Kd | = | 58.0 | nM | 7.24 |
| CHEMBL1822493 | — | Kd | = | 85.0 | nM | 7.07 |
| CHEMBL1822644 | — | Kd | = | 111.0 | nM | 6.96 |
| CHEMBL1822492 | — | Kd | = | 143.0 | nM | 6.84 |
| CHEMBL1822643 | — | Kd | = | 301.0 | nM | 6.52 |
| CHEMBL1822646 | — | Kd | = | 381.0 | nM | 6.42 |