Assay Detail
Binding
CHEMBL1827310
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PDE3A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (CHEMBL241) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and in vitro evaluation of new analogues as inhibitors for phosphodiesterase 10A.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.77 | 6.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL19224 | PAPAVERINE | 3.0 | 1 | 6.04 |
| CHEMBL1821775 | — | — | 1 | 5.92 |
| CHEMBL1821774 | — | — | 1 | 5.89 |
| CHEMBL1821789 | — | — | 1 | 5.76 |
| CHEMBL1821787 | — | — | 1 | 5.71 |
| CHEMBL1821790 | — | — | 1 | 5.66 |
| CHEMBL1821791 | — | — | 1 | 5.40 |
| CHEMBL1821776 | — | — | 1 | - |
| CHEMBL1821777 | — | — | 1 | - |
| CHEMBL1821778 | — | — | 1 | - |
| CHEMBL1821779 | — | — | 1 | - |
| CHEMBL1821780 | — | — | 1 | - |
| CHEMBL1821781 | — | — | 1 | - |
| CHEMBL1821782 | — | — | 1 | - |
| CHEMBL1821783 | — | — | 1 | - |
| CHEMBL1821784 | — | — | 1 | - |
| CHEMBL1821785 | — | — | 1 | - |
| CHEMBL1821786 | — | — | 1 | - |
| CHEMBL1821788 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL19224 | PAPAVERINE | IC50 | = | 917.0 | nM | 6.04 |
| CHEMBL1821775 | — | IC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL1821774 | — | IC50 | = | 1290.0 | nM | 5.89 |
| CHEMBL1821789 | — | IC50 | = | 1740.0 | nM | 5.76 |
| CHEMBL1821787 | — | IC50 | = | 1940.0 | nM | 5.71 |
| CHEMBL1821790 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL1821791 | — | IC50 | = | 3980.0 | nM | 5.40 |
| CHEMBL1821776 | — | IC50 | - | — | - | |
| CHEMBL1821777 | — | IC50 | - | — | - | |
| CHEMBL1821778 | — | IC50 | - | — | - | |
| CHEMBL1821779 | — | IC50 | - | — | - | |
| CHEMBL1821780 | — | IC50 | - | — | - | |
| CHEMBL1821781 | — | IC50 | - | — | - | |
| CHEMBL1821782 | — | IC50 | - | — | - | |
| CHEMBL1821783 | — | IC50 | - | — | - | |
| CHEMBL1821784 | — | IC50 | - | — | - | |
| CHEMBL1821785 | — | IC50 | - | — | - | |
| CHEMBL1821786 | — | IC50 | - | — | - | |
| CHEMBL1821788 | — | IC50 | - | — | - |