Assay Detail
Functional
CHEMBL1827500
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inverse agonist activity at HCMV TB40/E US28 expressed in human HEK cells assessed as Elk-1 activation preincubated for 1 hrs measured after 20 to 24 hrs by luciferase reporter gene assay
41
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human betaherpesvirus 5 |
| Cell Type | HEK293 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Identification of novel allosteric modulators for the G-protein coupled US28 receptor of human cytomegalovirus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 41 | 5.65 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1824282 | — | — | 2 | 6.89 |
| CHEMBL1824267 | — | — | 2 | 6.56 |
| CHEMBL93240 | METITEPINE | 2.0 | 2 | 6.46 |
| CHEMBL1824272 | — | — | 2 | 6.00 |
| CHEMBL1824284 | — | — | 2 | 5.85 |
| CHEMBL1824269 | — | — | 2 | 5.82 |
| CHEMBL1824498 | — | — | 2 | 5.82 |
| CHEMBL1824279 | — | — | 2 | 5.75 |
| CHEMBL1824280 | — | — | 2 | 5.70 |
| CHEMBL1821755 | — | — | 2 | 5.64 |
| CHEMBL1824275 | — | — | 2 | 5.47 |
| CHEMBL1824270 | — | — | 2 | 5.36 |
| CHEMBL34166 | BERLEX COMPOUND | — | 2 | 5.35 |
| CHEMBL1824268 | — | — | 2 | 5.32 |
| CHEMBL1824274 | — | — | 2 | 5.13 |
| CHEMBL1824278 | — | — | 2 | 5.12 |
| CHEMBL1824281 | — | — | 2 | 5.11 |
| CHEMBL1824273 | — | — | 2 | 5.07 |
| CHEMBL1824276 | — | — | 2 | 4.87 |
| CHEMBL1824271 | — | — | 1 | - |
| CHEMBL1824277 | — | — | 1 | - |
| CHEMBL1824283 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1824282 | — | EC50 | = | 128.82 | nM | 6.89 |
| CHEMBL1824282 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1824267 | — | EC50 | = | 275.42 | nM | 6.56 |
| CHEMBL1824267 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL93240 | METITEPINE | EC50 | = | 350.0 | nM | 6.46 |
| CHEMBL93240 | METITEPINE | EC50 | = | 354.81 | nM | 6.45 |
| CHEMBL1824272 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1824272 | — | EC50 | = | 1023.29 | nM | 5.99 |
| CHEMBL1824284 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1824284 | — | EC50 | = | 1412.54 | nM | 5.85 |
| CHEMBL1824269 | — | EC50 | = | 1513.56 | nM | 5.82 |
| CHEMBL1824498 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL1824269 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL1824498 | — | EC50 | = | 1548.82 | nM | 5.81 |
| CHEMBL1824279 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL1824279 | — | EC50 | = | 1778.28 | nM | 5.75 |
| CHEMBL1824280 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1824280 | — | EC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL1821755 | — | EC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL1821755 | — | EC50 | = | 2290.87 | nM | 5.64 |
| CHEMBL1824275 | — | EC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL1824275 | — | EC50 | = | 3467.37 | nM | 5.46 |
| CHEMBL1824270 | — | EC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL1824270 | — | EC50 | = | 4365.16 | nM | 5.36 |
| CHEMBL34166 | BERLEX COMPOUND | EC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL34166 | BERLEX COMPOUND | EC50 | = | 4570.88 | nM | 5.34 |
| CHEMBL1824268 | — | EC50 | = | 4786.3 | nM | 5.32 |
| CHEMBL1824268 | — | EC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL1824274 | — | EC50 | = | 7413.1 | nM | 5.13 |
| CHEMBL1824274 | — | EC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL1824278 | — | EC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL1824278 | — | EC50 | = | 7585.78 | nM | 5.12 |
| CHEMBL1824281 | — | EC50 | = | 7762.47 | nM | 5.11 |
| CHEMBL1824281 | — | EC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL1824273 | — | EC50 | = | 8511.38 | nM | 5.07 |
| CHEMBL1824273 | — | EC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL1824276 | — | EC50 | = | 13489.63 | nM | 4.87 |
| CHEMBL1824276 | — | EC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL1824271 | — | EC50 | - | — | - | |
| CHEMBL1824277 | — | EC50 | - | — | - | |
| CHEMBL1824283 | — | EC50 | - | — | - |