Assay Detail
Binding
CHEMBL1827651
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Binding affinity to BACE1 after 90 seconds by surface plasmon resonance assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
From fragment screening to in vivo efficacy: optimization of a series of 2-aminoquinolines as potent inhibitors of beta-site amyloid precursor protein cleaving enzyme 1 (BACE1).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 18 | 4.21 | 5.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1821810 | — | — | 1 | 5.38 |
| CHEMBL1821808 | — | — | 1 | 5.21 |
| CHEMBL1821805 | — | — | 1 | 5.14 |
| CHEMBL1821804 | — | — | 1 | 4.97 |
| CHEMBL1821803 | — | — | 1 | 4.97 |
| CHEMBL1821813 | — | — | 1 | 4.85 |
| CHEMBL1821802 | — | — | 1 | 4.65 |
| CHEMBL1821809 | — | — | 1 | 4.42 |
| CHEMBL1821801 | — | — | 1 | 4.41 |
| CHEMBL1821800 | — | — | 1 | 3.68 |
| CHEMBL189197 | — | — | 1 | 3.58 |
| CHEMBL1821799 | — | — | 1 | 3.58 |
| CHEMBL1821807 | — | — | 1 | 3.53 |
| CHEMBL1821798 | — | — | 1 | 3.27 |
| CHEMBL61236 | — | — | 1 | 3.05 |
| CHEMBL1821806 | — | — | 1 | 2.70 |
| CHEMBL1821811 | — | — | 1 | - |
| CHEMBL1821812 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1821810 | — | Kd | = | 4200.0 | nM | 5.38 |
| CHEMBL1821808 | — | Kd | = | 6100.0 | nM | 5.21 |
| CHEMBL1821805 | — | Kd | = | 7200.0 | nM | 5.14 |
| CHEMBL1821804 | — | Kd | = | 10800.0 | nM | 4.97 |
| CHEMBL1821803 | — | Kd | = | 10600.0 | nM | 4.97 |
| CHEMBL1821813 | — | Kd | = | 14200.0 | nM | 4.85 |
| CHEMBL1821802 | — | Kd | = | 22600.0 | nM | 4.65 |
| CHEMBL1821809 | — | Kd | = | 38400.0 | nM | 4.42 |
| CHEMBL1821801 | — | Kd | = | 38800.0 | nM | 4.41 |
| CHEMBL1821800 | — | Kd | = | 209000.0 | nM | 3.68 |
| CHEMBL189197 | — | Kd | = | 266000.0 | nM | 3.58 |
| CHEMBL1821799 | — | Kd | = | 266000.0 | nM | 3.58 |
| CHEMBL1821807 | — | Kd | = | 296000.0 | nM | 3.53 |
| CHEMBL1821798 | — | Kd | = | 540000.0 | nM | 3.27 |
| CHEMBL61236 | — | Kd | = | 900000.0 | nM | 3.05 |
| CHEMBL1821806 | — | Kd | = | 2000000.0 | nM | 2.70 |
| CHEMBL1821811 | — | Kd | - | — | - | |
| CHEMBL1821812 | — | Kd | - | — | - |