Assay Detail
ADMET
CHEMBL1827700
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Inhibition of human ERG
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of a series of 4-[3-(quinolin-2-yl)-1,2,4-oxadiazol-5-yl]piperazinyl ureas as potent smoothened antagonist hedgehog pathway inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.71 | 4.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1823591 | — | — | 1 | 4.92 |
| CHEMBL1823616 | — | — | 1 | 4.50 |
| CHEMBL1823865 | — | — | 1 | - |
| CHEMBL1822468 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1823591 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL1823616 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL1823865 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL1822468 | — | IC50 | > | 30000.0 | nM | - |