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Assay Detail

CHEMBL1827776

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Staphylococcus aureus Quorum sensing system AgrC-I activation after 60 to 90 minutes by beta-lactamase reporter assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Staphylococcus aureus
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Medicinal chemistry as a conduit for the modulation of quorum sensing.
Lowery CA, Salzameda NT, Sawada D, Kaufmann GF, Janda KD.
J Med Chem (2010) 53 : 7467 -7489
PubMed 20669927 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 6.58 7.68

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1824155 1 7.68
CHEMBL1824146 1 7.40
CHEMBL1824147 1 7.11
CHEMBL1823955 1 6.72
CHEMBL1823954 1 6.57
CHEMBL1824149 1 6.50
CHEMBL1824148 1 6.19
CHEMBL1824152 1 5.94
CHEMBL1824153 1 5.86
CHEMBL1824154 1 5.78
CHEMBL1824150 1 -
CHEMBL1824151 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1824155 IC50 = 21.0 nM 7.68
CHEMBL1824146 IC50 = 40.0 nM 7.40
CHEMBL1824147 IC50 = 77.0 nM 7.11
CHEMBL1823955 IC50 = 189.0 nM 6.72
CHEMBL1823954 IC50 = 272.0 nM 6.57
CHEMBL1824149 IC50 = 319.0 nM 6.50
CHEMBL1824148 IC50 = 639.0 nM 6.19
CHEMBL1824152 IC50 = 1141.0 nM 5.94
CHEMBL1824153 IC50 = 1390.0 nM 5.86
CHEMBL1824154 IC50 = 1680.0 nM 5.78
CHEMBL1824150 IC50 - -
CHEMBL1824151 IC50 - -