Assay Detail
Binding
CHEMBL1827862
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Displacement of 125I-[LTT]-SRIF-28 from human sst2 receptor in CCL39 cells after 2 hrs by autoradiography
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CCL39 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
N-imidazolebenzyl-histidine substitution in somatostatin and in its octapeptide analogue modulates receptor selectivity and function.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.86 | 9.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1823872 | SOMATOSTATIN | 3.0 | 1 | 9.17 |
| CHEMBL1823873 | — | — | 1 | 8.96 |
| CHEMBL1824052 | — | — | 1 | 8.80 |
| CHEMBL1824050 | — | — | 1 | 8.39 |
| CHEMBL1824051 | — | — | 1 | 7.82 |
| CHEMBL1824049 | — | — | 1 | 7.46 |
| CHEMBL452157 | — | — | 1 | 7.39 |
| CHEMBL1824054 | — | — | 1 | 6.97 |
| CHEMBL1824055 | — | — | 1 | 6.89 |
| CHEMBL1824056 | — | — | 1 | 6.76 |
| CHEMBL1824053 | — | — | 1 | - |
| CHEMBL1824057 | — | — | 1 | - |
| CHEMBL1824058 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1823872 | SOMATOSTATIN | IC50 | = | 0.67 | nM | 9.17 |
| CHEMBL1823873 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL1824052 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL1824050 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL1824051 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1824049 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL452157 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL1824054 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL1824055 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1824056 | — | IC50 | = | 173.0 | nM | 6.76 |
| CHEMBL1824053 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1824057 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1824058 | — | IC50 | > | 1000.0 | nM | - |