Assay Detail
Functional
CHEMBL1828087
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human HT-29 cells after 72 hrs by neutral red dye assay
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
New insights into the structural requirements for pro-apoptotic agents based on 2,4-diaminoquinazoline, 2,4-diaminopyrido[2,3-d]pyrimidine and 2,4-diaminopyrimidine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 43 | 5.14 | 6.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1824478 | — | — | 1 | 6.24 |
| CHEMBL1824455 | — | — | 1 | 5.79 |
| CHEMBL1824489 | — | — | 1 | 5.77 |
| CHEMBL1824457 | — | — | 1 | 5.66 |
| CHEMBL1824447 | — | — | 1 | 5.64 |
| CHEMBL1824485 | — | — | 1 | 5.60 |
| CHEMBL1824474 | — | — | 1 | 5.55 |
| CHEMBL1824454 | — | — | 1 | 5.54 |
| CHEMBL1824488 | — | — | 1 | 5.52 |
| CHEMBL1824456 | — | — | 1 | 5.46 |
| CHEMBL1824450 | — | — | 1 | 5.45 |
| CHEMBL1824458 | — | — | 1 | 5.42 |
| CHEMBL1824486 | — | — | 1 | 5.39 |
| CHEMBL1824479 | — | — | 1 | 5.37 |
| CHEMBL1824453 | — | — | 1 | 5.36 |
| CHEMBL1624459 | — | — | 1 | 5.33 |
| CHEMBL1824490 | — | — | 1 | 5.30 |
| CHEMBL1824461 | — | — | 1 | 5.29 |
| CHEMBL1824452 | — | — | 1 | 5.24 |
| CHEMBL1824448 | — | — | 1 | 5.23 |
| CHEMBL1824449 | — | — | 1 | 5.16 |
| CHEMBL1824495 | — | — | 1 | 5.16 |
| CHEMBL1824483 | — | — | 1 | 5.12 |
| CHEMBL390090 | — | — | 1 | 5.05 |
| CHEMBL1824493 | — | — | 1 | 5.01 |
| CHEMBL1824482 | — | — | 1 | 4.96 |
| CHEMBL1824496 | — | — | 1 | 4.91 |
| CHEMBL1824494 | — | — | 1 | 4.90 |
| CHEMBL1824473 | — | — | 1 | 4.90 |
| CHEMBL1824472 | — | — | 1 | 4.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1824478 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL1824455 | — | IC50 | = | 1640.0 | nM | 5.79 |
| CHEMBL1824489 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL1824457 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL1824447 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL1824485 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL1824474 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL1824454 | — | IC50 | = | 2880.0 | nM | 5.54 |
| CHEMBL1824488 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL1824456 | — | IC50 | = | 3470.0 | nM | 5.46 |
| CHEMBL1824450 | — | IC50 | = | 3570.0 | nM | 5.45 |
| CHEMBL1824458 | — | IC50 | = | 3780.0 | nM | 5.42 |
| CHEMBL1824486 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL1824479 | — | IC50 | = | 4230.0 | nM | 5.37 |
| CHEMBL1824453 | — | IC50 | = | 4420.0 | nM | 5.36 |
| CHEMBL1624459 | — | IC50 | = | 4720.0 | nM | 5.33 |
| CHEMBL1824490 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL1824461 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL1824452 | — | IC50 | = | 5810.0 | nM | 5.24 |
| CHEMBL1824448 | — | IC50 | = | 5890.0 | nM | 5.23 |
| CHEMBL1824495 | — | IC50 | = | 6970.0 | nM | 5.16 |
| CHEMBL1824449 | — | IC50 | = | 6960.0 | nM | 5.16 |
| CHEMBL1824483 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL390090 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL1824493 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL1824482 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL1824496 | — | IC50 | = | 12390.0 | nM | 4.91 |
| CHEMBL1824494 | — | IC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL1824473 | — | IC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL1824472 | — | IC50 | = | 13600.0 | nM | 4.87 |
| CHEMBL1824492 | — | IC50 | = | 14940.0 | nM | 4.83 |
| CHEMBL1824484 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL1824491 | — | IC50 | = | 17200.0 | nM | 4.76 |
| CHEMBL1824477 | — | IC50 | = | 18400.0 | nM | 4.74 |
| CHEMBL1824451 | — | IC50 | = | 18920.0 | nM | 4.72 |
| CHEMBL1824463 | — | IC50 | = | 19900.0 | nM | 4.70 |
| CHEMBL1824469 | — | IC50 | = | 20200.0 | nM | 4.70 |
| CHEMBL1824462 | — | IC50 | = | 22500.0 | nM | 4.65 |
| CHEMBL1824470 | — | IC50 | = | 24400.0 | nM | 4.61 |
| CHEMBL1824468 | — | IC50 | = | 25200.0 | nM | 4.60 |
| CHEMBL1824460 | — | IC50 | = | 25300.0 | nM | 4.60 |
| CHEMBL1824459 | — | IC50 | = | 26200.0 | nM | 4.58 |
| CHEMBL1824467 | — | IC50 | = | 32100.0 | nM | 4.49 |