Assay Detail
Functional
CHEMBL1828088
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human MDA-MB-231 cells after 72 hrs by neutral red dye assay
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
New insights into the structural requirements for pro-apoptotic agents based on 2,4-diaminoquinazoline, 2,4-diaminopyrido[2,3-d]pyrimidine and 2,4-diaminopyrimidine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 43 | 5.45 | 6.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1824496 | — | — | 1 | 6.44 |
| CHEMBL1824490 | — | — | 1 | 5.96 |
| CHEMBL1824449 | — | — | 1 | 5.96 |
| CHEMBL1824485 | — | — | 1 | 5.92 |
| CHEMBL1824474 | — | — | 1 | 5.92 |
| CHEMBL1824478 | — | — | 1 | 5.92 |
| CHEMBL1824458 | — | — | 1 | 5.91 |
| CHEMBL1824461 | — | — | 1 | 5.89 |
| CHEMBL1824462 | — | — | 1 | 5.85 |
| CHEMBL1824494 | — | — | 1 | 5.82 |
| CHEMBL1624459 | — | — | 1 | 5.75 |
| CHEMBL1824491 | — | — | 1 | 5.72 |
| CHEMBL1824493 | — | — | 1 | 5.70 |
| CHEMBL1824479 | — | — | 1 | 5.68 |
| CHEMBL1824447 | — | — | 1 | 5.66 |
| CHEMBL1824463 | — | — | 1 | 5.58 |
| CHEMBL1824486 | — | — | 1 | 5.57 |
| CHEMBL390090 | — | — | 1 | 5.54 |
| CHEMBL1824495 | — | — | 1 | 5.52 |
| CHEMBL1824450 | — | — | 1 | 5.50 |
| CHEMBL1824483 | — | — | 1 | 5.50 |
| CHEMBL1824454 | — | — | 1 | 5.41 |
| CHEMBL1824457 | — | — | 1 | 5.38 |
| CHEMBL1824448 | — | — | 1 | 5.37 |
| CHEMBL1824451 | — | — | 1 | 5.35 |
| CHEMBL1824469 | — | — | 1 | 5.35 |
| CHEMBL1824455 | — | — | 1 | 5.33 |
| CHEMBL1824488 | — | — | 1 | 5.29 |
| CHEMBL1824453 | — | — | 1 | 5.26 |
| CHEMBL1824468 | — | — | 1 | 5.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1824496 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL1824490 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1824449 | — | IC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL1824485 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL1824474 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL1824478 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL1824458 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL1824461 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1824462 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1824494 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL1624459 | — | IC50 | = | 1790.0 | nM | 5.75 |
| CHEMBL1824491 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL1824493 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1824479 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL1824447 | — | IC50 | = | 2180.0 | nM | 5.66 |
| CHEMBL1824463 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL1824486 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL390090 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL1824495 | — | IC50 | = | 3010.0 | nM | 5.52 |
| CHEMBL1824450 | — | IC50 | = | 3130.0 | nM | 5.50 |
| CHEMBL1824483 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL1824454 | — | IC50 | = | 3870.0 | nM | 5.41 |
| CHEMBL1824457 | — | IC50 | = | 4180.0 | nM | 5.38 |
| CHEMBL1824448 | — | IC50 | = | 4260.0 | nM | 5.37 |
| CHEMBL1824451 | — | IC50 | = | 4430.0 | nM | 5.35 |
| CHEMBL1824469 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL1824455 | — | IC50 | = | 4650.0 | nM | 5.33 |
| CHEMBL1824488 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL1824453 | — | IC50 | = | 5470.0 | nM | 5.26 |
| CHEMBL1824468 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL1824489 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL1824473 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL1824470 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL1824452 | — | IC50 | = | 7560.0 | nM | 5.12 |
| CHEMBL1824472 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL1824484 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL1824477 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL1824460 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL1824456 | — | IC50 | = | 10360.0 | nM | 4.99 |
| CHEMBL1824482 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL1824467 | — | IC50 | = | 15700.0 | nM | 4.80 |
| CHEMBL1824459 | — | IC50 | = | 18700.0 | nM | 4.73 |
| CHEMBL1824492 | — | IC50 | = | 19090.0 | nM | 4.72 |