Assay Detail
Binding
CHEMBL1828155
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to BRAF V600E mutant
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase B-raf (CHEMBL5145) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
4-Quinazolinyloxy-diaryl ureas as novel BRAFV600E inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 28 | 7.17 | 7.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1824291 | — | — | 1 | 7.54 |
| CHEMBL1824075 | — | — | 1 | 7.52 |
| CHEMBL1824296 | — | — | 1 | 7.47 |
| CHEMBL1824073 | — | — | 1 | 7.44 |
| CHEMBL1824078 | — | — | 1 | 7.42 |
| CHEMBL1824290 | — | — | 1 | 7.42 |
| CHEMBL1824068 | — | — | 1 | 7.40 |
| CHEMBL1824072 | — | — | 1 | 7.34 |
| CHEMBL1824286 | — | — | 1 | 7.34 |
| CHEMBL1824287 | — | — | 1 | 7.34 |
| CHEMBL1824289 | — | — | 1 | 7.32 |
| CHEMBL1824079 | — | — | 1 | 7.25 |
| CHEMBL1824297 | — | — | 1 | 7.25 |
| CHEMBL1824293 | — | — | 1 | 7.24 |
| CHEMBL1824295 | — | — | 1 | 7.24 |
| CHEMBL1824070 | — | — | 1 | 7.21 |
| CHEMBL1824288 | — | — | 1 | 7.17 |
| CHEMBL1824285 | — | — | 1 | 7.14 |
| CHEMBL1824069 | — | — | 1 | 7.14 |
| CHEMBL1824294 | — | — | 1 | 7.09 |
| CHEMBL1824074 | — | — | 1 | 7.05 |
| CHEMBL1824076 | — | — | 1 | 7.02 |
| CHEMBL1824292 | — | — | 1 | 7.02 |
| CHEMBL1824077 | — | — | 1 | 7.01 |
| CHEMBL1824080 | — | — | 1 | 7.00 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 6.55 |
| CHEMBL1277253 | — | — | 1 | 6.43 |
| CHEMBL1824071 | — | — | 1 | 6.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1824291 | — | Kd | = | 29.0 | nM | 7.54 |
| CHEMBL1824075 | — | Kd | = | 30.0 | nM | 7.52 |
| CHEMBL1824296 | — | Kd | = | 34.0 | nM | 7.47 |
| CHEMBL1824073 | — | Kd | = | 36.0 | nM | 7.44 |
| CHEMBL1824078 | — | Kd | = | 38.0 | nM | 7.42 |
| CHEMBL1824290 | — | Kd | = | 38.0 | nM | 7.42 |
| CHEMBL1824068 | — | Kd | = | 40.0 | nM | 7.40 |
| CHEMBL1824072 | — | Kd | = | 46.0 | nM | 7.34 |
| CHEMBL1824286 | — | Kd | = | 46.0 | nM | 7.34 |
| CHEMBL1824287 | — | Kd | = | 46.0 | nM | 7.34 |
| CHEMBL1824289 | — | Kd | = | 48.0 | nM | 7.32 |
| CHEMBL1824079 | — | Kd | = | 56.0 | nM | 7.25 |
| CHEMBL1824297 | — | Kd | = | 56.0 | nM | 7.25 |
| CHEMBL1824293 | — | Kd | = | 57.0 | nM | 7.24 |
| CHEMBL1824295 | — | Kd | = | 57.0 | nM | 7.24 |
| CHEMBL1824070 | — | Kd | = | 61.0 | nM | 7.21 |
| CHEMBL1824288 | — | Kd | = | 67.0 | nM | 7.17 |
| CHEMBL1824285 | — | Kd | = | 72.0 | nM | 7.14 |
| CHEMBL1824069 | — | Kd | = | 73.0 | nM | 7.14 |
| CHEMBL1824294 | — | Kd | = | 82.0 | nM | 7.09 |
| CHEMBL1824074 | — | Kd | = | 90.0 | nM | 7.05 |
| CHEMBL1824076 | — | Kd | = | 96.0 | nM | 7.02 |
| CHEMBL1824292 | — | Kd | = | 96.0 | nM | 7.02 |
| CHEMBL1824077 | — | Kd | = | 98.0 | nM | 7.01 |
| CHEMBL1824080 | — | Kd | = | 99.0 | nM | 7.00 |
| CHEMBL1336 | SORAFENIB | Kd | = | 284.0 | nM | 6.55 |
| CHEMBL1277253 | — | Kd | = | 370.0 | nM | 6.43 |
| CHEMBL1824071 | — | Kd | = | 478.0 | nM | 6.32 |