Assay Detail
Functional
CHEMBL1828178
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against of human KARPAS299 cells after 96 hrs by cell counting kit-8 assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KARPAS-299 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
9-substituted 6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazoles as highly selective and potent anaplastic lymphoma kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.46 | 8.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1823220 | — | — | 1 | 8.38 |
| CHEMBL1823221 | — | — | 1 | 7.89 |
| CHEMBL1823219 | — | — | 1 | 7.83 |
| CHEMBL1823222 | — | — | 1 | 7.60 |
| CHEMBL1779201 | — | — | 1 | 7.32 |
| CHEMBL1823223 | — | — | 1 | 6.93 |
| CHEMBL1823361 | — | — | 1 | 6.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1823220 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL1823221 | — | IC50 | = | 12.8 | nM | 7.89 |
| CHEMBL1823219 | — | IC50 | = | 14.8 | nM | 7.83 |
| CHEMBL1823222 | — | IC50 | = | 25.3 | nM | 7.60 |
| CHEMBL1779201 | — | IC50 | = | 47.9 | nM | 7.32 |
| CHEMBL1823223 | — | IC50 | = | 118.0 | nM | 6.93 |
| CHEMBL1823361 | — | IC50 | = | 544.0 | nM | 6.26 |