Assay Detail
Functional
CHEMBL1828263
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Cytotoxicity against human SiHa cells after 48 hrs by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SiHa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of derivatives of 4-deoxypodophyllotoxin as antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.14 | 7.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1822410 | — | — | 1 | 7.71 |
| CHEMBL1822417 | — | — | 1 | 7.08 |
| CHEMBL1822413 | — | — | 1 | 6.87 |
| CHEMBL1822414 | — | — | 1 | 6.80 |
| CHEMBL1822416 | — | — | 1 | 6.80 |
| CHEMBL1822415 | — | — | 1 | 6.68 |
| CHEMBL1822411 | — | — | 1 | 5.91 |
| CHEMBL89905 | 4'-DEMETHYLDEOXYPODOPHYLLOTOXIN | — | 1 | 5.68 |
| CHEMBL1822412 | — | — | 1 | 5.32 |
| CHEMBL1822409 | — | — | 1 | 5.30 |
| CHEMBL63970 | DESOXYPODOPHYLLOTOXIN | — | 1 | 4.99 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 4.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1822410 | — | IC50 | = | 19.5 | nM | 7.71 |
| CHEMBL1822417 | — | IC50 | = | 83.9 | nM | 7.08 |
| CHEMBL1822413 | — | IC50 | = | 135.0 | nM | 6.87 |
| CHEMBL1822414 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL1822416 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL1822415 | — | IC50 | = | 211.0 | nM | 6.68 |
| CHEMBL1822411 | — | IC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL89905 | 4'-DEMETHYLDEOXYPODOPHYLLOTOXIN | IC50 | = | 2070.0 | nM | 5.68 |
| CHEMBL1822412 | — | IC50 | = | 4760.0 | nM | 5.32 |
| CHEMBL1822409 | — | IC50 | = | 4970.0 | nM | 5.30 |
| CHEMBL63970 | DESOXYPODOPHYLLOTOXIN | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 30700.0 | nM | 4.51 |