Assay Detail
Functional
CHEMBL1828306
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Antiproliferative activity against HUVEC grown in presence of growth factors after 48 hrs by spectrophotometry
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HUVEC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 7-hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 8.03 | 9.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1823154 | — | — | 1 | 9.51 |
| CHEMBL1823147 | — | — | 1 | 9.51 |
| CHEMBL1823139 | — | — | 1 | 9.42 |
| CHEMBL1823148 | — | — | 1 | 9.40 |
| CHEMBL1823140 | — | — | 1 | 8.96 |
| CHEMBL1823146 | — | — | 1 | 8.77 |
| CHEMBL1823159 | — | — | 1 | 8.72 |
| CHEMBL1823155 | — | — | 1 | 8.59 |
| CHEMBL1823156 | — | — | 1 | 8.59 |
| CHEMBL1823158 | — | — | 1 | 8.51 |
| CHEMBL1823153 | — | — | 1 | 8.44 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.44 |
| CHEMBL1823157 | — | — | 1 | 7.54 |
| CHEMBL1823143 | — | — | 1 | 7.52 |
| CHEMBL1823142 | — | — | 1 | 7.50 |
| CHEMBL1823141 | — | — | 1 | 7.39 |
| CHEMBL1823144 | — | — | 1 | 7.35 |
| CHEMBL1823151 | — | — | 1 | 7.35 |
| CHEMBL409088 | — | — | 1 | 7.35 |
| CHEMBL1823145 | — | — | 1 | 7.08 |
| CHEMBL1823152 | — | — | 1 | 6.32 |
| CHEMBL1823150 | — | — | 1 | 6.29 |
| CHEMBL1823149 | — | — | 1 | 6.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1823154 | — | IC50 | = | 0.31 | nM | 9.51 |
| CHEMBL1823147 | — | IC50 | = | 0.31 | nM | 9.51 |
| CHEMBL1823139 | — | IC50 | = | 0.38 | nM | 9.42 |
| CHEMBL1823148 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL1823140 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL1823146 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL1823159 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL1823155 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL1823156 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL1823158 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL1823153 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL1823157 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL1823143 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1823142 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL1823141 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL1823144 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL1823151 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL409088 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL1823145 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL1823152 | — | IC50 | = | 484.0 | nM | 6.32 |
| CHEMBL1823150 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL1823149 | — | IC50 | = | 665.0 | nM | 6.18 |