Assay Detail
Functional
CHEMBL1828322
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Antiproliferative activity against MDR-1 overexpressing human 786-0 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | 786-0 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 7-hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.13 | 9.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1823147 | — | — | 1 | 9.24 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.35 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.51 |
| CHEMBL90555 | VINCRISTINE | 4.0 | 1 | 7.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1823147 | — | IC50 | = | 0.58 | nM | 9.24 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL90555 | VINCRISTINE | IC50 | = | 37.0 | nM | 7.43 |