Assay Detail
Binding
CHEMBL1828494
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Displacement of [125I]-alpha-bungarotoxin from alpha7 nAchR expressed in rat GH4C1 cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | GH4-C1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor subunit alpha-7 (CHEMBL2492) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and biological activity of a novel class nicotinic acetylcholine receptors (nAChRs) ligands structurally related to anatoxin-a.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.08 | 5.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1823380 | — | — | 1 | 5.34 |
| CHEMBL1823381 | — | — | 1 | 4.82 |
| CHEMBL1823379 | — | — | 1 | - |
| CHEMBL1823382 | — | — | 1 | - |
| CHEMBL1823383 | — | — | 1 | - |
| CHEMBL1823384 | — | — | 1 | - |
| CHEMBL1823385 | — | — | 1 | - |
| CHEMBL1823386 | — | — | 1 | - |
| CHEMBL1823387 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1823380 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL1823381 | — | IC50 | = | 15100.0 | nM | 4.82 |
| CHEMBL1823379 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1823382 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1823383 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1823384 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1823385 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1823386 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1823387 | — | IC50 | > | 10000.0 | nM | - |