Assay Detail
Functional
CHEMBL1831674
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at mouse prostanoid TP receptor expressed in QBI-HEK 293A cells assessed as inhibition of 1-BOP-induced increase in inositol monophosphate after 1 hr by time-resolved fluorescence assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Cyclopentane-1,3-dione: a novel isostere for the carboxylic acid functional group. Application to the design of potent thromboxane (A2) receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.04 | 8.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1829806 | — | — | 1 | 8.51 |
| CHEMBL1829812 | — | — | 1 | 8.24 |
| CHEMBL1829801 | — | — | 1 | 8.10 |
| CHEMBL1829808 | — | — | 1 | 8.03 |
| CHEMBL1829810 | — | — | 1 | 7.75 |
| CHEMBL65121 | — | — | 1 | 7.57 |
| CHEMBL1829805 | — | — | 1 | 7.28 |
| CHEMBL1829802 | — | — | 1 | 7.04 |
| CHEMBL1829811 | — | — | 1 | 6.59 |
| CHEMBL1829809 | — | — | 1 | 6.33 |
| CHEMBL1829804 | — | — | 1 | 5.91 |
| CHEMBL1828642 | — | — | 1 | 5.79 |
| CHEMBL1829807 | — | — | 1 | 5.75 |
| CHEMBL1829813 | — | — | 1 | 5.60 |
| CHEMBL1829803 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1829806 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL1829812 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL1829801 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1829808 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL1829810 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL65121 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL1829805 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL1829802 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL1829811 | — | IC50 | = | 259.0 | nM | 6.59 |
| CHEMBL1829809 | — | IC50 | = | 463.0 | nM | 6.33 |
| CHEMBL1829804 | — | IC50 | = | 1229.0 | nM | 5.91 |
| CHEMBL1828642 | — | IC50 | = | 1627.0 | nM | 5.79 |
| CHEMBL1829807 | — | IC50 | = | 1786.0 | nM | 5.75 |
| CHEMBL1829813 | — | IC50 | = | 2524.0 | nM | 5.60 |
| CHEMBL1829803 | — | IC50 | > | 10000.0 | nM | - |